Transcription and replication are controlled by kinetic regulatory mechanisms.
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چکیده
منابع مشابه
Transcription regulatory elements are punctuation marks for DNA replication.
Collisions between DNA replication and transcription significantly affect genome organization, regulation, and stability. Previous studies have described collisions between replication forks and elongating RNA polymerases. Although replication collisions with the transcription-initiation or -termination complexes are potentially even more important because most genes are not actively transcribe...
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Transcription factor GATA-1 is required for the terminal differentiation of both the primitive and definitive erythroid cell lineages, and yet the regulatory mechanisms of GATA-1 itself are not well understood. To clarify how the GATA-1 gene is transcriptionally controlled in vivo, presumptive regulatory regions of the gene were tested by fusion to a reporter gene and then examined in transgeni...
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An important part of understanding a biological pathway or a cellular function is to delineate the transcriptional regulatory mechanisms of the genes involved. Key participants in these mechanisms are special transcription factor proteins (TFs) which recognize particular sequences, called TF binding sites in promoters. Computational approaches to identify TF binding sites have been facilitated ...
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While collisions between replication and transcription in bacteria are deemed inevitable, the fine details of the interplay between the two machineries are poorly understood. In this study, we evaluate the effects of transcription on the replication fork progression in vivo, by using electrophoresis analysis of replication intermediates. Studying Escherichia coli plasmids, which carry constitut...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 1987
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.27.194